Influence of morphological characteristics on the deposition of low-density lipoprotein in intracranial bifurcation aneurysms

The increasingly demonstrated association of wall enhancement (WE) measured by vascular imaging with the instability/rupture intracranial aneurysms (IAs) implies significance investigating transport and accumulation blood substances [e.g., low-density lipoprotein (LDL), (a)] related to WE in IAs. In present study, we perform numerical simulations explore relationships between distribution/severity LDL deposition on lumen surface morphological characteristics aneurysm its adjacent arteries as well underlying fluid dynamic mechanisms. Bifurcation located at middle cerebral artery are selected subject investigation for which both idealized patient-specific models built. Studies reveal that aneurysm–parent (AP) angle is more powerful than other parameters daughter–parent (DP) angle, nonsphericity index (NI) aneurysm] determining severity deposition. A bleb (i.e., secondary sac) can enhance local deposition, especially when an deposition-prone region. models, dominant effect AP remains identifiable, whereas effects DP NI overwhelmed confounding factors. Enhanced prefers appear regions perpendicular intra-aneurysmal vortex centerline. comparison shear stress magnitude, normal-to-tangential near-wall velocity ratio particle residence time better predict localization enhanced